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UID:20260406T232727AEST-3393oi1U2u@https://archive.synchrotron.org.au/
DTSTAMP:20260406T132727Z
DESCRIPTION:A&#160\;research scientist in the CREATIS Laboratory and scient
 ific collaborator at the ESRF\, Dr Françoise Peyrin leads a team on ‘Tomog
 raphic Imaging and Therapy with radiations’. Her research interest include
 s 3D imaging techniques in X-ray tomography\, tomographic image reconstruc
 tion\, image analysis and wavelet based methods for biomedical application
 s. In particular\, Françoise is developing new methods for the characteriz
 ation of bone tissue at the microscopic scale.\nHer talk on \'3D Synchrotr
 on Radiation imaging in bone research: Past works and perspectives\' will 
 comprise the following.\n\'After introducing truly 3D X-ray Computerized T
 omography (CT)\, we shall present the advantages of Synchrotron Radiation 
 (SR) X-ray CT. The 3D SR micro-CT setup developed on beamline ID19 at the 
 ESRF will be described. This system\, which can image objects in a large r
 ange of energies (8-60 keV) and spatial resolutions (voxel size from 0.17μ
 m – 30 μm) has many applications in various domains. I shall focus on deve
 lopments motivated by bone research to have a better understanding of bone
  fragility. Bone has a hierarchical organization covering a large range of
  scales. At a scale between 5-10μm level\, SR micro-CT is well suited to a
 nalyze the micro-structure in cancellous and cortical bone. In addition\, 
 thanks to the properties of synchrotron radiation\, the images provide sim
 ultaneously the quantification of the degree of mineralization of bone whi
 ch is fundamental parameter to assess bone remodeling. These properties wi
 ll be illustrated by various studies on human or animal bone. The capabili
 ty of imaging bone micro-structural in-vivo on a mice model was also demon
 strated. We shall then describe work in progress to analyze bone at the ul
 tra-structural level. At the micrometer or sub-micrometer scale it is poss
 ible to assess osteocyte lacunae\, bone micro-cracks and possibly the thre
 e-dimensional organization of the canalicular system. Finally the exploita
 tion of phase contrast imaging in bone research will also be briefly intro
 duced. This motivated the development of a regularized phase retrieval app
 roach adapted to hard samples with first applications in bone tissue engin
 eering.\'\n\nSynchrotron Radiation Micro-CT images of human vertebral bone
  sample from micro structure (left : voxel size : 6.7 μm) to ultrastructur
 e (right : voxel size : 1.4μm) [Peyrin F\, Osteoporos Int (2009) 20:1057–1
 06]\n\nFor more information\, please contact: daniel.hausermann@synchrotro
 n.org.au
DTSTART:20100331T110000Z
DTEND:20100331T120000Z
LOCATION:Monash Centre for Synchrotron Science  (770 Blackburn Road Clayton
   VIC)
SUMMARY:3D Synchrotron Radiation imaging in bone research: Past works and p
 erspectives
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